I describe a method for creating self-replicating fractal tiles based on iterating tessellating arrangements of polyominoes. In general, while these tiles will tessellate at every stage, they will only be self replicating in the limit of an infinite number of iterations. I further analyze all of the possibilities through heptominoes. A wide range of fractal forms result, some familiar and some not. A space-filling fractal tile and a spatial development of the twindragon tile are described as well.