Creating mirror dual-sided inverse color (MDSI) mosaics using Rubik’s cubes offers new opportunities to explore the nature of the 3x3x3 cube, providing fresh insights into its symmetry and internal structure. The MDSI method is the first comprehensive approach for solving dual-sided cube patterns and constructing artistic mosaics from cubes. The proposed algorithms have been instrumental in designing author’s own artworks for several contemporary art exhibitions. The MDSI approach could be valuable for cube mosaic creators, Rubik’s cube artists, and enthusiasts interested in delving deeper into the mathematical nature of the cube.